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Image Search Results
Journal: Clinical pharmacology and therapeutics
Article Title: Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity
doi: 10.1038/clpt.2014.158
Figure Lengend Snippet: Predicted maximum hepatic accumulation of CDCA and LCA species and DILI responses (i.e., minimum hepatic ATP, minimum viable liver mass, maximum serum ALT) post-dose in human SimPops at oral doses of 200 (green triangle), 400 (blue circle), or 600 (red diamond) mg/day TGZ for 6months (A), and rat SimPops at oral doses of 5 (blue circle) or 25 (red diamond) mg/kg/day for 6months (B).
Article Snippet: Human (n=331) and rat (n=191) population samples with variability in 10 (human) or 11 (rat) parameters in the BA homeostasis sub-model (Bile Acid SimPops) were constructed previously within
Techniques:
Journal: Clinical pharmacology and therapeutics
Article Title: Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity
doi: 10.1038/clpt.2014.158
Figure Lengend Snippet: Summary of troglitazone (TGZ)-mediated hepatotoxicity in human SimPops and clinical trials.
Article Snippet: Human (n=331) and rat (n=191) population samples with variability in 10 (human) or 11 (rat) parameters in the BA homeostasis sub-model (Bile Acid SimPops) were constructed previously within
Techniques:
Journal: Clinical pharmacology and therapeutics
Article Title: Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity
doi: 10.1038/clpt.2014.158
Figure Lengend Snippet: In human SimPops administered 400 (A) or 600 (B) mg/day troglitazone (TGZ) for 6months, individuals with serum ALT elevations > 3× ULN (n=10 at 400mg/day; n=17 at 600mg/day) are presented. One individual at 400mg/day and two individuals at 600mg/day lost >85% of viable liver mass and was classified as dead.
Article Snippet: Human (n=331) and rat (n=191) population samples with variability in 10 (human) or 11 (rat) parameters in the BA homeostasis sub-model (Bile Acid SimPops) were constructed previously within
Techniques:
Journal: Clinical pharmacology and therapeutics
Article Title: Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid-Mediated Troglitazone Hepatotoxicity
doi: 10.1038/clpt.2014.158
Figure Lengend Snippet: Inhibition constants for BSEP, MRP4, and NTCP were altered 10-fold in either direction of the values measured in isolated transport systems . Predicted maximum serum ALT concentrations in human and rat SimPops after an oral dose of 600mg/day and 5 mg/kg/day troglitazone (TGZ), respectively, for 1month are presented. Dashed lines represent 3× baseline ALT in human (90 U/L) and rat (63 U/L) SimPops.
Article Snippet: Human (n=331) and rat (n=191) population samples with variability in 10 (human) or 11 (rat) parameters in the BA homeostasis sub-model (Bile Acid SimPops) were constructed previously within
Techniques: Inhibition, Isolation
Journal: STAR Protocols
Article Title: Analysis of target mRNAs in the fixed-frozen human brain using a modified BaseScope-ISH Assay protocol
doi: 10.1016/j.xpro.2022.101896
Figure Lengend Snippet:
Article Snippet:
Techniques: Hood, Plasmid Preparation, Software, Staining, Hybridization
Journal: STAR Protocols
Article Title: Quantifying spatial position in a branched structure in immunostained mouse tissue sections
doi: 10.1016/j.xpro.2021.100806
Figure Lengend Snippet:
Article Snippet:
Techniques: Transduction, Recombinant, Sterility, Blocking Assay, Software, Dissection, Staining, Microscopy